Peanut rAra h 3 IgE, f424
Ara h 6 is a reserve protein of conglutin seeds and a member of the 2S albumin family, which is able to withstand the harsh conditions of the gastrointestinal tract. Individuals sensitive to Ara h 6 are at increased risk of more severe symptoms and anaphylactic reactions.
Allergocomponent diagnostics is based on the detection of sensitization to allergens at the molecular level using natural highly purified and recombinant allergen molecules, that is, their individual allergen components.
There are 3 main benefits of doing this analysis:
- Allergocomponent diagnostics makes it possible to differentiate true sensitization from sensitization due to cross-reactivity. This data will help determine the sources of allergies: one single allergy, several closely related ones, or many different ones.
- Molecular allergy diagnostics will eliminate the need for provocative tests and allow you to give clearer recommendations regarding the elimination of contact with allergens.
- Molecular allergodiagnostics is necessary in the selection of ASIT in persons with polyvalent (multiple) sensitization, the most accurate way to determine the most important allergen for which therapy will be performed.
The allergenic substance contains not one but several protein components that can act as allergens:
- Major allergen components are the main allergenic molecules, antibodies to which are found in more than half – 50% of patients in the population responding to this source. They are resistant to heat and more immunogenic. They are large and are contained in this allergen in larger quantities.
- Minor are secondary smaller in size and less immunogenic allergenic molecules that are usually contained in smaller amounts in the allergen but are present in many different allergens, sometimes not closely related, providing cross-allergy. That is, allergens with a prevalence of more than 50% are called major allergens and less than 10% are called minor allergens.
Initially, Ara h 6 was not considered one of the main allergens of peanuts, but now it is considered one of the strongest. Patients with peanut allergy who are sensitized to Ara h 6 are often also sensitized to Ara h 2, however, in rare cases, sensitization to Ara h 6 without sensitization to Ara h 2 can cause serious reactions to peanuts. The use of IgE specific to Ara h 2 and 6 can help diagnose peanut allergy.