Peanut rAra h 1 IgE, f422

Ara h 8 is a homologous Bet v 1 allergen (the main allergen of birch) and a member of the PR-10 protein group and is usually associated with increased sensitization in areas with increased exposure to tree pollen.

Allergy component diagnostics is based on the detection of sensitization to allergens at the molecular level using natural highly purified and recombinant allergen molecules, i.e. their allergy components.

There are 3 main advantages of doing this analysis:

Allergocomponent diagnostics, makes it possible to differentiate true sensitization from sensitization due to cross-reactivity. This data will help determine the sources of allergies: one single allergy, several closely related ones, or many different ones.
Molecular allergy diagnostics will eliminate the need for provocative tests and allow you to give clearer recommendations regarding the elimination of contact with allergens.
Molecular allergodiagnostics is necessary in the selection of ASIT, in persons with polyvalent (multiple) sensitization, the most accurate way to determine the most important allergen for which therapy will be performed.

The allergenic substance contains not one but several protein components that can act as allergens:

Major allergen components are the main allergenic molecules, antibodies to which are found in more than half – 50% of patients in the population responding to this source. They are resistant to heat and more immunogenic. They are large and are contained in this allergen in larger quantities.
Minor are secondary smaller in size and less immunogenic allergenic molecules that are usually contained in smaller amounts in the allergen but are present in many different allergens, sometimes not closely related, providing cross-allergy. That is, allergens with a prevalence of more than 50% are called major allergens and less than 10% are called minor allergens.

Ara h 8 is found in small amounts in peanuts and cannot withstand digestive enzymes and stomach pH conditions. Proteins related to Bet v 1 (the major birch allergen), such as Ara h 8, usually cause mild symptoms, usually associated with oral allergy syndrome, and there is evidence that people with monosensitization to Ara h 8 demonstrate tolerance to peanuts. Ara h 8 IgE has limited diagnostic use in diagnosing true peanut allergy, although it may be useful in diagnosing peanut symptoms due to cross-reactions to birch pollen. Cross-reactivity has been shown with Bet v 1 (birch pollen) and its homologues Gly m 4 from soybeans and Pru av 1 from cherries.