Walnut rJug r 1 IgE, f441
Jug r 1 is a heat-stable spare protein of 2S albumin, which is also stable during digestion.
sIgE to Jug r 1 is closely associated with primary allergy to walnuts and pecans and the risk of systemic symptoms.
Allergen component testing is based on the identification of sensitization to allergens at the molecular level using natural, highly purified and recombinant allergen molecules, i.e. their individual allergen components.
There are three main advantages to performing this analysis:
- Allergen component diagnostics makes it possible to differentiate true sensitization from sensitization due to cross-reactivity. This data will help identify the sources of allergies: a single source, several closely related sources, or many different sources.
- Molecular allergy diagnostics eliminates the need for provocation tests and allows for more precise recommendations regarding the elimination of contact with allergens.
- Molecular allergy diagnostics is necessary in the selection of ASIT, in individuals with polyvalent (multiple) sensitization, to determine the most important allergen for which therapy will be carried out in the most accurate way.
The allergenic substance contains not one, but several protein components that can act as allergens:
- Major allergenic components are the main allergenic molecules, antibodies to which are found in more than half (50%) of patients in the population who react to a given source. They are resistant to heating and more immunogenic. They are large in dimension and are contained in this allergen in larger quantities.
- Minor allergens are secondary, smaller in dimension and less immunogenic allergenic molecules, which are usually present in smaller quantities within an allergen, but are found in many different allergens, sometimes not closely related, causing cross-allergy. That is, allergens with a prevalence of more than 50% are called major, and less than 10% are called minor.
Sensitization to Jug r 1 occurs via the gastrointestinal tract. High stability and structural stability due to cysteine residues make it resistant to the harsh acidic environment of the gastrointestinal tract. Consequently, they can penetrate the intestinal mucosal barrier, affect the immune system, and cause allergic reactions.
Analysis method: ImmunoCAP method (solid phase immunofluorescence)
Unit of measurement: kU/l
Biological material for analysis: venous blood