Fungal mold Aspergillus fumigatus, m3
Aspergillus fumigatus (A. fumigatus) is a saprotrophic and opportunistic mycelial fungus that is widespread in the environment. A. fumigatus is a spore-forming, thermotolerant fungus that reproduces asexually by conidial spores. It is a cosmopolitan pathogen found on all five continents (Europe, Asia, America, Africa, and Australia).
Inhalation is the main route of exposure to Aspergillus spores. A. fumigatus is the causative agent of allergic and infectious diseases affecting tens of millions of people worldwide. Allergic bronchopulmonary aspergillosis (ABLA) is the most severe allergic disease associated with aspergillosis, affecting 1-2.5% of asthma patients and up to 10% of cystic fibrosis patients during their lifetime.
Other serious allergic diseases associated with Aspergillus are allergic fungal rhinosinusitis (AFRS) and severe asthma with fungal sensitization (SAFS). To date, 23 A. fumigatus allergens have been characterized.
Among them, Asp f 1 and Asp f 2 are the main allergens, Asp f 3 has extensive cross-reactivity, and Asp f 4 and Asp f 6 are associated with the diagnosis of ABLA. Moreover, Asp f 1 and Asp f 2 are markers of true sensitization to A. fumigatus. Cross-reactivity was mainly observed between A. fumigatus and other fungal species.
Determination of specific IgE in human blood to Aspergillus fumigatus, m3, shows the body's reaction to this allergen.
Analysis method: ImmunoCAP method (solid phase immunofluorescence)
Unit of measurement: kU/l
Biological material for analysis: venous blood