Fungal mold Penicillium notatum, m1

Penicillium species are fungus found in open and closed ground. P. chrysogenum (notatum) is one of the most important and well-known Penicillium species due to its use for penicillin production. Species belonging to the genus Penicillium are ubiquitous in soil and air; however, the number of fungal spores varies with rainfall and location. They thrive near organic materials or moist building environments, but can survive with very little water. The spores of P. chrysogenum are smooth and spheroidal.

The prevalence of IgE sensitization to Penicillium spp. It was found that 1.5% and 7.3-22% in the general population and in individuals with atopy, respectively. The main route of exposure to P. chrysogenum allergens is inhalation, while exposure to ingestion and skin contact is rare.
P. chrysogenum can cause respiratory allergic symptoms such as allergic rhinitis, asthma and allergic bronchopulmonary mycosis in sensitized individuals. Penicillium sensitization in children is less common than in adults, usually less than 10% among asthmatics or atopy. Pen ch 13 and Pen ch 18 (serine and/or vacuolar proteases) are major allergens of P. chrysogenum, but they are not species-specific because of their cross-reactivity with other molds. It should be noted that the cross-reactivity between sensitization to Penicillium and drug allergic reactions to β-lactam penicillin, which is a secondary metabolite of Fungus, is synthesized only under certain circumstances.

Determination of specific IgE in human blood to - Fungal mold Penicillium notatum, m1, shows the body's reaction to this allergen.

Analysis method: ImmunoCAP method (Immunofluorescence in the solid phase)

Units of measurement: kU/l

Biomaterial for analysis: venous blood