Coagulation factor VII (F VII Arg353Gln G>A)
Proconvertin or coagulation factor VII-protein, activator of blood clotting factors in vitamin K presence. Changes in factor VII structure ensures genetic ‘resistance’ to myocardial infarction, risk of thromboembolic complications, therefore, has protective effect.
Potential genotypes:
• G/G –F7 protein activity is normal
• G/A – F7 protein activity is moderately reduced
• A/A – F7 protein activity is significantly reduced