Coagulation factor XIII (F XIII Val35Leu G>T)

Сoagulation factor XIII is protein responsible for the final stage in the clotting cascade. Polymorphisms (changes) in the gene encoding FXIII have protective effect in most cases. They reduce the risk of deep vein thrombosis and myocardial infarction. Substitutions transform the FXIII protein properties, its ability to "cross-link" fibrin monomers, therefore, thinner fibrin clots are formed.

Potential genotypes:

• G/G – "normal" activity of the F13 protein

• G/T –  F13 protein activity is moderately reduced

• T/T –  F13 protein activity is significantly reduced