Comprehensive diagnosis of steroid hormones: androgens, glucocorticoids, mineralocorticoids, estrogens, progestagens, their precursors and metabolites (15 parameters) (chromatography)
Comprehensive steroid hormone diagnostics covers a wide range of tests, including androgens, glucocorticoids, mineralocorticoids, estrogens, progestogens, their precursors and metabolites (15 indicators in total). These hormones play a crucial role in regulating many physiological processes, such as metabolism, sexual function, immune responses, and the body's response to stress. Testing all of these hormones helps diagnose various endocrine diseases, metabolic disorders, and hormonal imbalances.
For comprehensive diagnosis of steroid hormones, high-performance liquid chromatography with mass spectrometry (HPLC-MS) is used, which is the most advanced and accurate tool for measuring hormone levels and their metabolites. This method allows simultaneous analysis of several indicators with high accuracy and eliminates possible errors inherent in other methods.
Androgens and their metabolites:
- Testosterone - the main male sex hormone, indicator of hyperandrogenism.
- Dihydrotestosterone (DHT) - the active form of testosterone, associated with androgenic alopecia and BPH.
- Androstenedione - a precursor of testosterone and estrogens, a marker of CAH.
- Dehydroepiandrosterone sulfate (DHEA-S) - an indicator of adrenal hyperandrogenism.
- 17-OH progesterone - a key marker of congenital adrenal hyperplasia, especially in cases of 21-hydroxylase deficiency.
Glucocorticoids:
- Cortisol - the main stress hormone, used to diagnose Cushing's syndrome and Addison's disease.
- Cortisone - an inactive metabolite of cortisol, assessment of 11β-hydroxysteroid dehydrogenase activity.
Mineralocorticoids:
- Aldosterone - regulates water and salt balance, used to diagnose hyperaldosteronism.
- 11-deoxycorticosterone (DOC) - a precursor of aldosterone, a marker of rare forms of CAH.
Estrogens:
- Estradiol (E2) - the main female sex hormone, an indicator of ovarian function.
- Estrone (E1) - a secondary estrogen, especially important during menopause and obesity.
Progestogens:
- Progesterone - marker of ovulation and corpus luteum function.
- 17-OH-progesterone (also belongs to the androgenic track) - diagnosis of CAH.
Additional metabolites:
- Pregnenolone - the starting hormone for the synthesis of all steroid hormones.
- 11-deoxycortisol - a marker of 11β-hydroxylase deficiency, a form of CAH.