Peach rPru p 3 LTP IgE, f420
The peach allergen, Pru p 3, is a nonspecific lipid transfer protein type 1 (nsLTP 1) and acts as a precursor to other nsLTP-related sensitizations.
Typical clinical symptoms of Pru p 3-induced allergy include oral allergy syndrome (OAS), anaphylaxis (gastrointestinal lesions, nausea, vomiting, and diarrhea), generalized or contact urticaria, and occasionally severe asthma.
Allergy component diagnosis is based on the detection of sensitization to allergens at the molecular level using natural highly purified and recombinant allergen molecules, i.e. their individual allergy components.
There are 3 main advantages of this analysis:
- Allergy component diagnostics gives the ability to differentiate true sensitization from sensitization due to cross-reactivity. This data will help to identify the sources of allergy which can be a single allergy, several closely related allergies, or many different allergies.
- Molecular allergodiagnosis eliminates the need for provocation tests and allows for clearer recommendations regarding the elimination of contact with allergens.
- Molecular allergodiagnostics is necessary in the selection of ASIT, in persons with polyvalent (multiple) sensitization it is the most accurate way to determine the most important allergen for which therapy will be carried out.
The allergenic substance includes not one but several protein components that can act as allergens which are as follows:
Major allergic components are the major allergenic molecules, antibodies to which are found in more than half to 50% of patients in the population reacting to a given source. They are heat stable and more immunogenic. Major are large in size and are found in greater quantities in a given allergen.
Minor allergens are minor, smaller in size and less immunogenic allergenic molecules that are usually contained in smaller amounts within an allergen but are present in many different allergens, sometimes not closely related, providing cross-allergy. That is, allergens with a prevalence of more than 50% are called major allergens and less than 10% are called minor allergens.
Pru p 3 acts as a marker allergen for severe systemic symptoms and is one of the diagnostic indicators for detecting allergy to fruits of the rose-flower family.
Cross-reactivity of Pru p 3 is found in most members of the Rosaceae family, such as apple, plum, cherry, and apricot. It can also cross-react with representatives containing nsLTP from other families such as walnut, hazelnut, peanut, asparagus, lettuce, tomato, corn, onion and carrot.
Test method is ImmunoCAP (Immunofluorescence on solid phase) method
Units of measurement is kU/l
The sampling biomaterial is venous blood