Systemic autoimmune diseases (CTD + ANA)
Antinuclear Antibodies (ANA)
Antinuclear antibodies are autoantibodies directed against components of the body’s own cell nuclei. Their detection is a crucial laboratory test for diagnosing systemic autoimmune connective tissue diseases.
ANA Screening (CTD + ANF)
A comprehensive laboratory test aimed at detecting antibodies associated with systemic autoimmune connective tissue diseases.
The package combines two complementary methods:
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CTD Screen (ELISA)
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An enzyme-linked immunosorbent assay detecting antibodies against major nuclear antigens (dsDNA, SSA, SSB, Sm, RNP, Scl-70, Jo1, etc.).
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Allows rapid assessment of the likelihood of an autoimmune process.
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Antinuclear Factor (ANF)
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Detection of antibodies by indirect immunofluorescence on the HEp-2 cell line.
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Considered the “gold standard” for ANA diagnostics and allows determination of:
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Pattern of fluorescence
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Titer
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Antigen specificity
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Possible clinical association
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Applications
The package can be used for diagnosis and monitoring of:
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Systemic lupus erythematosus (SLE)
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Systemic scleroderma
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Sjögren’s syndrome
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Dermato-/polymyositis
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Mixed connective tissue diseases
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Autoimmune liver diseases and other autoimmune conditions