Systemic autoimmune diseases (CTD + ANA)
Antinuclear Antibodies (ANA)
Antinuclear antibodies are autoantibodies directed against components of the body’s own cell nuclei. Their detection is a crucial laboratory test for diagnosing systemic autoimmune connective tissue diseases.
ANA Screening (CTD + ANF)
A comprehensive laboratory test aimed at detecting antibodies associated with systemic autoimmune connective tissue diseases.
The package combines two complementary methods:
CTD Screen (ELISA)
- An enzyme-linked immunosorbent assay detecting antibodies against major nuclear antigens (dsDNA, SSA, SSB, Sm, RNP, Scl-70, Jo1, etc.).
- Allows rapid assessment of the likelihood of an autoimmune process.
Antinuclear Factor (ANF)
Detection of antibodies by indirect immunofluorescence on the HEp-2 cell line.
Considered the "gold standard" for ANA diagnostics and allows determination of:
- Pattern of fluorescence
- Titer
- Antigen specificity
- Possible clinical association
Applications
The package can be used for diagnosis and monitoring of:
- Systemic lupus erythematosus (SLE)
- Systemic scleroderma
- Sjögren’s syndrome
- Dermato-/polymyositis
- Mixed connective tissue diseases
- Autoimmune liver diseases and other autoimmune conditions