Dog rCan f 1, e101

Canis Familiaris Allergen 1 (Can f1) is a lipocalin protein of saliva and one of the main allergens present in dog hair and dandruff extracts. Allergy component diagnostics is based on the detection of sensitization to allergens at the molecular level using natural highly purified and recombinant allergen molecules, i.e., their individual allergy components.

There are 3 main advantages of doing this analysis:

• Allergocomponent diagnostics make it possible to differentiate true sensitization from sensitization due to cross-reactivity. This data will help determine the sources of allergies: one single allergy, several closely related ones, or many different ones.
• Molecular allergodiagnostics will eliminate the need for provocative tests and allow you to give clearer recommendations regarding the elimination of contact with allergens.
• Molecular allergodiagnostics is necessary in the selection of ASIT in persons with polyvalent (multiple) sensitization, the most accurate way to determine the most important allergen for which therapy will be performed.

The allergenic substance contains not one but several protein components that can act as allergens:

• Major allergen components are the main allergenic molecules, antibodies to which are found in more than half – 50% of patients in the population responding to this source. They are resistant to heat and more immunogenic. They are large in size and are contained in this allergen in larger quantities.
• Minor allergens are secondary smaller in size and less immunogenic allergenic molecules that are usually contained in smaller amounts in the allergen but are present in many different allergens, sometimes not closely related, providing cross-allergy. That is, allergens with a prevalence of more than 50% are called major allergens and less than 10% are called minor allergens.

Can f1 is secreted by sebaceous glands and is found in hair, dandruff, and saliva, but not in the skin, salivary glands, serum, or liver extracts. Can f1 particles can remain in the air for a relatively long period of time with minimal disruption, and because of their small size, they are easier to inhale than larger particles such as tick feces or pollen grains. Can f1 is found in all homes with dogs and in a third of homes without dogs. In about half of all people with dog allergies, IgE is directed exclusively at Can f1. IgE levels against lipocalins such as Can f1 correlate with asthma severity. Increased sensitization to Can f1 is closely related to an increase in the severity of the disease and the persistence of asthma symptoms in children and adults. In molecular diagnostics, recombinant Can f1 is immunologically compatible with a natural allergen and can be reliably used to identify people with allergies to dogs sensitized to Can f1.