Dog rCan f 2, e102

Canis Familiaris Allergen 2 (Can f 2) is a lipocalin protein of saliva and a minor allergen present in dog hair and dandruff extracts. 
Allergy component diagnostics is based on the detection of sensitization to allergens at the molecular level using natural highly purified and recombinant allergen molecules, i.e. their individual allergy components.

There are 3 main advantages of doing this analysis:
- Allergocomponent diagnostics, makes it possible to differentiate true sensitization from sensitization due to cross-reactivity. This data will help determine the sources of allergies: one single allergy, several closely related ones, or many different ones.
- Molecular allergy diagnostics will eliminate the need for provocative tests and allow you to give clearer recommendations regarding the elimination of contact with allergens.
- Molecular allergodiagnostics is necessary in the selection of ASIT, in persons with polyvalent (multiple) sensitization, the most accurate way to determine the most important allergen for which therapy will be performed.

The allergenic substance contains not one but several protein components that can act as allergens:
Major allergen components are the main allergenic molecules, antibodies to which are found in more than half – 50% of patients in the population responding to this source. They are resistant to heat and more immunogenic. They are large and are contained in this allergen in larger quantities.

Minor are secondary smaller in size and less immunogenic allergenic molecules that are usually contained in smaller amounts in the allergen but are present in many different allergens, sometimes not closely related, providing cross-allergy. That is, allergens with a prevalence of more than 50% are called major allergens and less than 10% are called minor allergens.
Sensitivity to Can f 2 is associated with high levels of bronchial inflammation and is more common in patients with severe asthma compared to well-controlled asthma.

Molecular diagnostics can use recombinant Can f 2 to reliably identify people with Can f 2 sensitized dog allergy, but it should be noted that all patients with reactivity to Can f 2 will also react to Can f 1.
Sensitization to Can f 2 was more common in children with severe asthma than in peers of the same age with controlled asthma.