Malonic dialdehyde (a stable end product of GENDER) in blood

Malonic dialdehyde (hereinafter referred to as MDA) is a secondary breakdown product of lipid peroxidation (hereinafter referred to as LPO). MDA accumulation in blood explains the intoxication syndrome accompanying many diseases of internal organs. Reacting with SH- and CH3-groups of proteins, MDA inhibits the activity of cytochrome oxidases (thus depressing tissue respiration) and hydroxylases. MDA also causes accelerated development of atherosclerosis.

When MDA interacts with amino groups of phospholipids, Schiff bases, end products of LPO, are formed. An example of these compounds is the pigment lipofuscin, which appears on the eye membrane, on the skin with age. Lipofuscin is a mixture of lipids and proteins bound together by transverse covalent bonds and denatured as a result of interaction with chemically active groups of LPO products. This pigment is phagocytized, but not hydrolyzed by lysosome enzymes, and accumulates in cells, disrupting their function.

Negative consequences of LPO activation:

Damage to the lipid bilayer of membranes, resulting in penetration of water, sodium ions, calcium ions into cells, leading to swelling of cells, organelles and their destruction.
Premature aging of cells and the body as a whole.
Interaction of highly reactive LPO products with amino groups of proteins with the formation of Schiff bases.
Change of membrane fluidity (viscosity), resulting in disruption of membrane transport function (functioning of ion channels).
Disruption of activity of membrane-bound enzymes, receptors.

Activation of LPO is characteristic of many diseases and pathological conditions such as:

Atherosclerosis and other cardiovascular diseases;
CNS lesions (Parkinson's disease, Alzheimer's disease);
inflammatory processes of any genesis;
muscular dystrophy (Duchenne's disease);
oncologic diseases;
radiation lesions;
bronchopulmonary pathologies.

Preparation: Blood is taken strictly on an empty stomach, at least 8 hours should be between the last meal and blood sampling. Juice, tea, coffee, especially with sugar as well as food should be excluded. Water intake does not affect blood counts. 1-2 days before the analysis it is desirable to exclude from the diet fatty and fried products and alcohol. A couple of hours before taking blood refrain from smoking. One day before blood sampling it is desirable to avoid physical exertion, it is also necessary to exclude physical stress (running, climbing stairs) and emotional excitement. Before the procedure you should rest for 10-15 minutes and calm down. Blood should not be taken immediately after X-ray, ultrasound, massage, reflexology or physiotherapy procedures. Refrain from taking medications if possible. If you have difficulty when discontinuing medications, please inform your doctor.