Determination of Ig G for the nuclear antigen of the Epstein-Barr virus (HSV-IV) in the serum by the ELISA method

Epstein Barr virus– belongs to the human herpes viruses of the 4th group. It tends to affect B lymphocytes and causes an acute disease in humans - infectious mononucleosis, and is also associated with the development of nasopharyngeal carcinoma, Burkitt's lymphoma, Hodgkin's disease, hairy leukoplakia and B-cell lymphoma. The virus is spread all over the world. In some countries, up to 95 % of the population aged 40 years have previously been infected with it and have antibodies. The infection is transmitted with saliva.

The incidence peaks in early childhood and adolescence.  IgG antibodies to the nuclear antigen appear 4-6 months after the onset of infection, including those that occur in latent forms, and then, in low titers, are detected for life. They can be found in more than 50% of adolescents and more than 90% of adults. IgG class antibodies to the nuclear antigen are detected late after acute infection, against the background of latent infection, as well as during reactivation and chronic infection. Used as a marker of past-infection.