Melanoma: Genetic Profile (BRAF, NRAS)
Melanoma genetic profiling (BRAF, NRAS) is a molecular genetic analysis designed to detect somatic mutations in the BRAF and NRAS genes. These genes are critical for regulating cell growth and proliferation, and their mutations are associated with melanoma pathogenesis. The results of the analysis are crucial for selecting a personalized therapeutic strategy and assessing the prognosis of the disease.
Clinical indications:
- Diagnosed melanoma: All patients with histologically confirmed melanoma, especially before starting systemic therapy.
- Metastatic or unresectable melanoma: to determine the optimal treatment strategy for advanced disease.
- Targeted therapy planning: mandatory before prescribing BRAF and MEK inhibitors to confirm the presence of target mutations.
Anamnestic indications:
- Family history of melanoma: The presence of melanoma in blood relatives may be an additional factor for thorough molecular profiling.