Walnut rJug r 3 LTP IgE, f442

Jug r 3 is a non-specific lipid transport protein (nsLTP), recognized as the main allergen of walnut, resistant to both heating and pepsin digestion. Patients sensitive to the Jug r 3 allergen may develop severe reactions such as food contact urticaria, oral allergy syndrome, gastrointestinal symptoms, and even anaphylaxis. Jug r 3 exhibits cross-reactivity with other allergens such as peach (Pru p 3), peanuts (Ara h 9), hazelnuts (Cor a 8), Pru ar 3 (apricot), cherry (Pru av 3), and almonds (Pru du 3).

Allergy component diagnostics is based on the detection of sensitization to allergens at the molecular level using natural highly purified and recombinant allergen molecules, i.e. their individual allergy components. There are 3 main advantages of performing this analysis:

• Allergocomponent diagnosis makes it possible to differentiate true sensitization from sensitization due to cross-reactivity. These data will help identify the sources of allergies: a single one, several closely related ones, or many different ones.
• Molecular allergodiagnostics will eliminate the need for provocative tests and allow you to give clearer recommendations regarding the elimination of contact with allergens.
• Molecular allergodiagnostics is necessary in the selection of ASIT, in persons with polyvalent (multiple) sensitization, the most accurate way to determine the most important allergen for which therapy will be performed.

The composition of the allergenic substance includes not one, but several protein components that can act as allergens:

• Major allergenic components are the main allergenic molecules, antibodies to which are found in more than half of 50% of patients in the population responding to this source. They are resistant to heat and more immunogenic. They are large and are contained in this allergen in larger quantities.
• Minor components are secondary smaller in size and less immunogenic allergenic molecules that are usually contained in smaller amounts in the allergen but are present in many different allergens, sometimes not closely related, providing cross-allergy. That is, allergens with a prevalence of more than 50% are called major, and less than 10% are called minor.

Research method: ImmunoCAP method (Immunofluorescence in the solid phase)
Units of measurement: kU/l
Biomaterial for analysis: venous blood