Грецкий орех rJug r 3 LTP IgE, f442

Jug r 3 represents a non-specific lipid transport protein (nsLTP), recognized as a major allergen of walnut, resistant to both heat and pepsin digestion. In patients sensitive to Jug r 3, severe reactions may develop, such as food contact urticaria, oral allergy syndrome, gastrointestinal symptoms, and even anaphylaxis. Jug r 3 exhibits cross-reactivity with other allergens, including peach (Pru p 3), peanut (Ara h 9), hazelnut (Cor a 8), apricot (Pru ar 3), cherry (Pru av 3), and almond (Pru du 3).

The basis of allergen component diagnostics lies in the detection of sensitization to allergens at the molecular level using natural highly purified and recombinant molecules of allergens, i.e., their individual allergenic components. There are three main advantages of performing this test:

Allergen component diagnostics allows for differentiation between true sensitization and sensitization due to cross-reactivity, which helps determine the sources of allergy: a single one, several related ones, or multiple different ones.
Molecular allergodiagnostics excludes the need for provocation tests and provides more precise recommendations regarding avoidance of allergens.
Molecular allergodiagnostics is essential for selecting the most important allergen for therapy in patients with multiple sensitivities.

Composition of Allergenic Substances

An allergenic substance consists of not one, but several protein components that can act as allergens:

Major allergenic components: These are the main allergenic molecules, antibodies to which are found in more than 50% of patients in a population reacting to a given source. They are heat-resistant and more immunogenic, larger in size, and present in greater quantities in the allergen.
Minor allergenic components: These are secondary, smaller in size, and less immunogenic allergenic molecules that are present in smaller quantities in the allergen, but are often found in many different allergens, sometimes not closely related, ensuring cross-allergy. In other words, allergens with a prevalence of more than 50% are considered major, while those with a prevalence of less than 10% are considered minor.

Method of Research

Method: ImmunoCAP (Immuno-fluorescence on a solid phase)

Units of measurement: kU/l

Biomaterial for research: venous blood